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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d75b45eded07601ab8f57e77dd396f7a33076bc699b6270c9b1330abc6aec58' 
  AND token = '6/3ZKQMB1VU5+JT78WCGzGhVFe6POHhs02m18jaFl1A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}