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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd16fde644c181f8fe5482eec89dbe54477d1e901cb8754d36abe5e03939efabe' 
  AND token = 'tSAd0xSUMSBiYdGNUs4BQfFJhntGqLuHLEAne9IVkmI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}