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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78f6b542768009a51c3a610d76814b5120eeeea8148b6329c617942b5836a697' 
  AND token = 'bE++3vPBKFNRvRaN1MbMpxCf4WHbc0LP0h/oIEMpucU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}