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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45c6f3bbc856f1d429c23a18953af190eabcb4b351a3c366903cf4e0a146808f' 
  AND token = 'Zx0ldCQE8PxXhOMWU/asGPYLsU0X4+jv4anIr6zRqI0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}