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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f91bb49008b0a35fb5f2322c08fea387fab037a7f7053d50daca52cceb8ac5e' 
  AND token = 'qdYa/ew+e6l/XEQ4njiY5wTv2+XyeKjgcnDQRSPVJ4k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}