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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd6003079aa434e167de3782e9d3a2eff9f5b9a70803562f408583b8f72186482' 
  AND token = 'MSTgnO0DlqzgOU+sPSB+TFW3o2fG5U2YOAq67xgR8Nk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}