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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9e5b42edb40705e76035d1a9b033ce8cec6ea0a1ba1abf029e2abc2a4499942d' 
  AND token = 'HN4iH6C1Ezk94Q0ZDsshT5V25GFZzMKjTqPaGFpo8aY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}