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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52b42ab0379b2a1c4165b6b009a32afd2bcb2bcedf04313799af5da2ad66ceca' 
  AND token = 'pUL8r6/vN7ZB7/oGYDj/I8HXRPoX7akpQQHdAag4v1I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}