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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b46d1fe1eaf02c4b1f00a9240360e66e2bb216a7176561add5c5366bea19e589' 
  AND token = '7NZ1p5lu4Vh+RouJIF/58cMtwMQ+zd0MOHDtpYDy3Zo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}