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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '399a5e54d826b03bbbfde8a64c7e4a8f2d131aa89a3366a61905f0289b059023' 
  AND token = '0eHNQmOBDaFPKKz6k0+EERnJ7zodJXgsIMNt1dNYspA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}