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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6306010a33aaaf35bb3d1b58b444de2da0e1742cb636c78ad3da69e6fb9009f0' 
  AND token = 'FYwUUJaAU81Ma4kWkPlf+s2GVjpgC57eXsSwJVxbOsw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}