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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9f26c54479405e9953ea9da27850673a2bdcd3853cff3ab94b58fb0e8af291da' 
  AND token = 'xn/UPiC3sl7419srYiDMkMuHBiK1hqZVoo9MydsMQnA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}