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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '427b284a4b5c5cfc008802629037965d5c50afa12a3ee434f13c4fea6bfc2e1f' 
  AND token = 'DxEn5nsPiz/5SlS+pk4o9QrnujTONbjv387Rrwx20Ic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}