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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53db3e938cfe0408cc858e8515a4567fe12721d120d67fbbbaae891b170a81b6' 
  AND token = 'Lq7FwOiqMaRCPy1rvb7FXQxFkHwr3M0a/5rupD4MQ7g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}