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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '499f64ca02c3f49b1a5bd4b65e2979300e4cbdd621016c45006ed7a54b2e4642' 
  AND token = 'wcr1ka7YZm2wMM7RG0/kD2eESJnu910DeImlSMm5/ok=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}