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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10d3ed1e080782a46fc34c2ba22f5eb972fe6b90051a56b95c20d00261ceaa87' 
  AND token = 'j/E7U6s2cDHD+F9Z65UYJ6ZTk3b9pVSRmzUZWuez8O0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}