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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af38d616b2905bc19e335dce5c8a3f21779650437258bb88cc79f5b521eccd22' 
  AND token = '+8W/i8mHoZBnPiSKSuVdF5M/Itq1Yc+xSFBb+d5snCE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}