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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d515d66c239997fac3f0d8b4706d65e4d883545b1a02ab6e16907957b95ab6b' 
  AND token = 'KQm01E7rKZfnc4zwcTxRWicbwwnkFvC4aNkT3ZB9UG0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}