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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '278650bac92a3b359af3890fff04d5c3f6324d7d7dc24de3f1b4b03f0c5c1e38' 
  AND token = '4/HRPWdXM0PzeuoUfxM2lP64L3qcelVhDvAmud85HAM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}