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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e5011307344a333483cca5631d49c7650a2f626ba1a980e32d297058c93ac5a' 
  AND token = 'elItxn+PDI6Qpb34E1C6O7W9EQLo2CcZKlr2X4pa0cM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}