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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a450ee32661d8dd2a58a410ebf56acbde3c26b96f867ce047caadf0689310839' 
  AND token = 'yQO3VUpIMI4y8Xc7FFSEns1RUgMbaj4a0Vwz6BjfzbA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}