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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21728fe812fc744ec174966e75b648b5bac4f602c1186537dba552a33ae94768' 
  AND token = 'j9Ku/rWBdpHZ2+fqIaUF8o1kjeHnmmUapYitHYP1rpk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}