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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '375e4d3f7285aa54ca74e58dac3acd987437cd33cd3a0bdf06ba7f9072d2fb3c' 
  AND token = 'zcbEQ70Ww4nWj0vS3LTPClqjDRJcm3gurbtuMEoLNgY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00053

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}