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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c295434a63d438ff8be7e6b13e4bd70ce727677d9689bd001950f6a835b1ea6f' 
  AND token = 'HSb+uPM65T5RBv+scWOVYsttrcd6sIOywOVoWSDoUYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}