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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81a9112daf7d2f30e9234032cdeabcd4700f321982b25f4033a5921d956a52d2' 
  AND token = 'Ljg0Ofh1wZu5I1DjmjaV82teGfLfS2oYrbHhqvNuV64=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}