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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1309c3b3d7ff3a525f2ea85eb02261e742f88487c54fe543f8760b66c87fd11' 
  AND token = 'IRlUdGtxPaWg7vIDQbrrcizv+j1Y2xRxJckkj7zF3uc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}