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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ea44dd2221cd521a0681dcd8d70774d4a3dc35bf81d0b050d8d1ab8e8a7495d4' 
  AND token = 'T0uV+kvYuWHIJm1BMqxZC7cL8jU1hRlXd+H/jYym/Tg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}