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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c29c4966baa4da594551c8c6b67a3ea41ea5e4495bb1d8b47b8212ce651c51' 
  AND token = 'esqdinXXdfpl0e0d4dvHY9OLRIMXV3Xyo0iPOrHJ6zI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}