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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '04da2751b4f6a5daf527211a5de2d7f7b80d9171edbfbf2b789b2d1fc14b2485' 
  AND token = '1Isr/b1Z/BCyq123MlJEIU6bDzI0kiRrJzIWBQmA0FY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}