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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '801a8c3d6b7392248ba095678e844098d7895542cac6014000b54608b3e77798' 
  AND token = 'miAP7HmfE0k15n1vDDKhNRvJv0y3sXEChgqhFDfhNjI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}