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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42161becdfd5ab02ed908af1dbeb8cfa1d6b00aaf1ae584cf3ca7397ac560381' 
  AND token = 'QKRHWiq1ZH2RO2+VTmAvs1zB4WArcwgWpDJk96etDwQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}