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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0443b09637526ca08f8e2e8a074b4378fb6fe2c2d14253b1293c52edf2dc1bfd' 
  AND token = 'H1eDkVwKXA5L/+ypIJeIgZ+O2IWTF7CBaHLAByRb17I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}