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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e8a870147cd3165a0053244a094cdb62fa41bd4b6fd0774f21e4c3a4572a0b0' 
  AND token = 'Ctc0I/0KS0DJHRpuQIbo2qd8IEkaEPbexAawNIr3aXE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}