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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad9981298ae1e50a0d9eedc0c0114538272a186650da6758b71a4b47c0d533d4' 
  AND token = 'gFCNCQS1wNSrx/YAMNQSSOykTxdpF3TYSWZ+Blojc7U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}