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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '151417c3d604d8ad88e85f07df1420058b7a750268b8e8c85c87dd06056f769c' 
  AND token = 'LugHtxDz3S8MR0UQdqqIQtTVMw2rEMZdd14HfpGF2xo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}