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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22969c739899e57082991e3e85d068158b8f9e61d4f1df21cac5547c91a818fc' 
  AND token = '2iJIEDp3GFgaJvz7a3ShH7NdeI/MSqnVDvFNrWGGh3U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}