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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '469c284d94a723f8f79dd48feeef2d2f15cb234adf12a2e5333736f9d4207bfd' 
  AND token = 'UuaoizEKn1N/mpWRFfgjs7p9KsQ8L1s68CictQ37+XQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}