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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a452cdccd6aac8afa8b8de40142b43590c4704379a54f2a4555466c664417f57' 
  AND token = 'VD/p0XTz5hkbApAIkEe7ecieOs4r/SDbOWpI6gzOUAU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}