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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c25b0420e14628f2447e1619604da0fafa7429e9a7b64c33cb007c1774093b2' 
  AND token = 'HDx198WP1EMXO/ICtVvDhPSm0b+xH8LfNOISLpvFO54=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}