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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16d65675233b0e8b56426f59e8a26da8920cafecac481a2ab59ef9710c92bc49' 
  AND token = 'NcPa1chxzfEVytURW+2b1/H3wzqWOCi2Stw3CcXeWUY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}