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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd59cdc79bbc8bed85a59a88f1105880087067c2df957f70725b276f04b38cc71' 
  AND token = 'oUaw7PwTigZSgXKIb2M+ElVjyNTkbqXTvMoNCar/8pQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}