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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '678e686ad72d07e6b090df57b86eae4a0b18c68c2f0c0da5eb90308024c2c499' 
  AND token = 'Rdrv5LfeiK8iowLJo74s/KIxom5xnobmNJMSv32Gm4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}