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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae4561135947e7e0b78c05a90f980200ea9d871ed3216e5135a590465334273f' 
  AND token = 'I4w/zvZ9/e9rlv+1HYRb6KVE7E3nqceCsQAIhUwI5XA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}