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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222e9c4587cbbbd04d5b189d75ad62abfb64ac648eddb949e4a8cb80b4df06be' 
  AND token = 'LXGH8++0Bs11YcTZz6aj4CULbiKAXGtsHcmQ4ddWtDs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}