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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '515c7c440a291e51c6b31238ad3cc705e41c4465bcd771bd30de6817a2b6d467' 
  AND token = 'DWyu24g8mMX0QgFnbfV6rI4fDccAr2uze8K6IhN/xfw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}