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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49a4c602e89c5d811b9f02860e850fc5ee05b8b24cf04015f598182d981e715c' 
  AND token = 'v+OzfuKwyEmiG9hh+c6iP/4bs+kHXKwA5x5xnwrPBRA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}