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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'acd6316fba0b705f4c55a682349f35e1b9e8edbd3bbb2e2e30d30f7b30014619' 
  AND token = 'sTMub+QA0nFFFZBOz1pvn8SS23ik0x5xTiSBeJOMAy4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}