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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '451d2b3d7e21696346d2d18e00b7aeb82b7df3238f971cbd09a47cdd22d9a8f2' 
  AND token = 'Sn7woIVQ5cmcyNQOfFlnkEx0Tbz3soXEKNUHqZFdiFc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}