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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42210622386ee81e40667d418145a0e9306c4f6c7dc41619ad71fae6b3f91a8f' 
  AND token = 'aOlVIRBnNTdDQgjOc+678DzY6GkUrK09rfwGqZS7T9g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}