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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e8403d0d1da6e1d4210d091ec3a2c1f46f1810aad5357cb5966571b159eefb6' 
  AND token = 'vYwIOO0UdDPnhI5zh6X6IEukZBiyfVBwlRjVO5UCOvM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}